A 39-year-old woman diagnosed as having Hashimoto thyroiditis 1 month prior developed spasms in her axial and lower limb muscles (see and diffuse hypertonia and rigidity in all extremities, illustrated by patellar clonus in response to deep tendon reflex testing in this video. She had elevated levels of thyroperoxidase, thyroglobulin, and anti–glutamic acid decarboxylase (GAD65) antibodies; normal imaging, cerebrospinal fluid (CSF) measures, and paraneoplastic antibody levels; and electromyography (EMG) findings showing continuous firing of normal motor unit potentials at rest within the axial and lower limb muscles (see consistent with a diagnosis of PERM. Her recent diagnosis of Hashimoto thyroiditis suggested an autoimmune etiology. Click for additional clinical images and patient videos and for complete details of the diagnosis, its differential, and the patient’s response to treatment.
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